Summary of Modern Studies on Longdan Xiaocuo ( AcNomore Formula™)

•  Radix Bupleuri is pungent-bitter-slightly-cold, pertains the liver-gallbladder channels, capable of soothing the liver, resolving stagnation, and clearing heat.
• Rhizoma Cimicifugae is pungent-sweet-cold, pertains the spleen channel, capable of clearing heat, detoxication. When it is concerted with Radix Bupleuri, the capacity of ascending yang and collapse is strengthened. So as to prevent the toxicity of ulcers invading the interior.
• Herba Gentiana is bitter-cold, pertains to the liver-gallbladder channels, capable of clearing heat dampness in the liver and gallbladder, reducing the excessive fire in the liver and gallbladder, so as to prevent liver subduing the spleen.

The above three ingredients are applied as the monarchal ingredients.

• Flos Chrysanthemum indicis, Herba Taraxaci, Radix Scrophularia, Folium Isatidis are all bitter-cold. When they are applied together, the action of clearing heat and detoxication is greatly strengthened, and are applied together as ministerial ingredients. Among them, Radix Scrophularica and Folium Isatidis also yield the action of cooling blood and resolving erythema.
• Radix Scutellaria is bitter-cold. It clears heat dries dampness, and cools blood, and strengthens the action of clearing heat, cooling blood of the recipe.
•  Radix Ophiopogonis, Herba Dendrobii are sweet cold, pertains to the kidney channel, capable of nourishing yin, clearing heat, benefiting the stomach and producing fluid.
•  crude Gypsum Fibrosum is pungent, sweet and highly cold, capable of clearing heat, reducing fire, eliminating fidgetiness, arresting thirst.
•  Folium Bambusal is sweet-slightly cold, capable of clearing heat, eliminating fidgetiness, arresting thirst.
• Caulis Bambusae in Taeniam clears heat, resolves phlegm, arrests vomit. They are used to strengthen the capacity of clearing heat.
• Radix Arnebiae sen Lithospermi is sweet-cold, capable of cooling blood and detoxifying.
• Spica Druiellae clears liver fire and disperses stagnant accumulation, they are used as adjuvant and servant ingredients. The whole recipe yields the action of clearing heat, detoxifying, cooling blood, eliminating erythema, soothing the liver and dispersing nodules.
   

Modern pharmacological studies show that Rhizoma Cimicifugae, Radix Bupleuri, Radix Ophiopogonis, raw Gypsum, Herba Dendrobii all yield effects on immunity.

Florcem Chryasanthemum indicis, Radix Scrophularia, Flos Loniceri, Herba Taraxaci, Radix Arnebiae Seu Lithospermi all possess anti-inflammatory effect. Among them, the water extract of the last herb decreases the exudates, inhibits the granulation in cotton ball granulation or crotonic oil granulated cyst in rat by oral route or alcohol extract given by peritoneal injection.

Shikonin, ethyl shikonin, β, βdimethyl acryloyl shikonin can inhibit the local exudates at the site of drug application, with anti-acute inflammation, promotion of gramdation proliferation, and healing of wounds, the shikonin and its ester being the active ingredients responsible for bacteriostatic action.

The chlorogenic and iso-chlorogenic acids in Flos Lonicerae are the active bacteriostatic ingredients. The compound recipe of Flos Lonicerae can elevate the peripheral WBC, increase the level of serum IgG, thus increase the immunity in mice. Its extract yields marked action of anti-exudation and anti-hyperplasia of granulocyst in rat induced by crotonic acid.

Folium Isatidis yields action of anti-endotoxin of O111B4 of E.coli, Radix Scrophularia yields anti-fungus action of the skin. Powder radix Ophiopogonis and Rosco sapogenin all yield bacteriostatic action. Above all the ingredients  cooperate to produce the action of anti-inflammation and detoxification.
 

Excerpt from "A Guide to TCM Products," China Academy of Traditional Chinese Medicine, 2003

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any diseases.